翻訳と辞書 Words near each other ・ Wolfram Kühn (cyclist) ・ Wolfram Language ・ Wolfram Lattke ・ Wolfram Lorenzen ・ Wolfram Löwe ・ Wolfram Müller ・ Wolfram Paulus ・ Wolfram Research ・ Wolfram Saenger ・ Wolfram Samlowski ・ Wolfram Setz ・ Wolfram Sievers ・ Wolfram Sperling ・ Wolfram Spyra ・ Wolfram Steinwendtner ・ Wolfram syndrome ・ Wolfram SystemModeler ・ Wolfram von Eschenbach ・ Wolfram von Soden ・ Wolfram Wagner ・ Wolfram Waibel Jr. ・ Wolfram Waibel, Sr. ・ Wolfram Wuttke ・ Wolfram's 2-state 3-symbol Turing machine ・ Wolfram, Queensland ・ Wolframite ・ Wolframmeyia imperialis ・ Wolframs-Eschenbach ・ Wolfran Cornewall ・ Wolfratshausen Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Wolfram syndrome ： ウィキペディア英語版 Wolfram syndrome Wolfram syndrome, also called DIDMOAD (diabetes insipidus, diabetes mellitus, optic atrophy, and deafness), is a rare genetic disorder, causing diabetes mellitus, optic atrophy, and deafness as well as various other possible disorders. It was first described in four siblings in 1938 by Dr. Don J. Wolfram, M.D.〔Wolfram, D. J.; Wagener, H. P. : Diabetes mellitus and simple optic atrophy among siblings: report of four cases. Mayo Clin. Proc. 13: 715-718, 1938.〕 The disease affects the central nervous system (especially the brainstem). ==Causes== Wolfram syndrome was initially thought to be caused by mitochondrial dysfunction due to its symptoms and several reports of mitochondrial mutations. However, it has now been established that Wolfram syndrome is caused by endoplasmic reticulum dysfunction.〔(Urano, F. Diabetes. 2014 Mar;63(3):844-6. )〕 Two genetic forms have been described: Wolfram syndrome 1 (WFS1),〔(OMIM 222300 (WFS1) )〕 and Wolfram syndrome 2 (WFS2)〔(OMIM 604928 (WFS2) )〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Wolfram syndrome」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.